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6 Claims
1. Excessive exposure to sunlight is dangerous but lack of it can be unsafe too
Communicating too much about the harmful effects of sunlight can make us forget its positive effects. However,
humankind cannot live without sunlight .
Insufficiency of UV rays triggers a shortage of vitamin D synthesis, melatonin deficiency, implicated in seasonal
depressions and worsens hyper-sensitivity phenomena.
2. Adapting the skin to sunlight rather than overprotecting it
The skin intuitively recognizes that it needs sunlight. Therefore it has learned to adapt itself, especially by using
hyper-reactive self-defense systems.
These defense systems lose their functionality with the application of sun block creams. The skin then loses its
adaptation ability.
The Photo Cellular Care line re-educates the skin to adapt to sunlight.
This is the unique foundation upon which Institut Esthederm creates sun care products.
3. Tanning is the best protection
It is the skin’s natural defense system.
At the origin of tanning is melanin, a colored pigment with exceptional UV and free radical absorption properties. It
deactivates the sun’s harmful effects at the base.
4. Tanning does not age the skin
Tanning is a natural skin reaction which protects the skin against sunlight.
It sometimes comes with side effects which can be harmful if not neutralized by the skin’s self-defense abilities.
Photo Cellular Care products are focused on the neutralization of the sun’s harmful effects while stimulating the skin’
s natural self-defense abilities, including tanning. In this way, Institut Esthederm creates tanning sun care products.
5. Inequality of skin type is not a fatality.
Our expertise in skin biology allows for re-educating even the most sensitive skin type and normalizing its reaction to
sunlight.
Its adaptation is concerned with enabling it to tolerate progressive sun radiations while controlling its hyper-sensitivity.
6. SPF index is not enough
The SPF index measures the risk of sunburn but neither the risks of aging nor the photo-aging sensitivity.
A skin can age without sunburn; hence without warning.
True to Institut Esthederm’s youth claim, the Photo Cellular Care line prevents and repairs skin aging while
controlling inflammation

KNOWING SUNLIGHT IS NECESSARY TO CONTROL IT…
•When UV rays reach the skin they can induce direct and indirect harmful biological
reactions.

Biological targets of direct and indirect (via free radicals) are primarily:
–Cell membranes’ unsaturated lipids, altered by fat-peroxidation, which lie at
the origin of the inflammation.
–DNA, with the breaking of strands responsible for the genome alteration.
–Proteins, whose loss of functionality accelerate photo-aging.
Consequences: These many cell aggressions are visibly shown by sunburns and
the skin’s accelerated aging, also called “photo-aging”
THE SKIN EXPOSED TO SUNLIGHT
Knowing skin is necessary to re-educate it…

To benefitfrom the positive effects of sunlight while
preserving itselffrom harmful effects, human skin has to
adapt
gradually while losing its primitive “coat”.
Complex protection strategies have been gradually put in
place
with…
The skin exposed to sunlight

The tan:
–The skin’sself-adaptation system to the sun.
–Based on the control of melanin production, a pigment acting as a natural anti-UV
ray filter.
–Protecting the DNA using the ”capping” process (protection of the nucleus).

•Natural self-defense systems:
–Against INDIRECT aggressionswith:
•anti-radicals systems (anti-ROS)

–Against
DIRECT aggressions or when anti-radicals defenses have not been
sufficient, with:
•Anti-inflammatory factors
•DNA direct protection and reparation
•Reparation of damaged proteins
ESTHEDERM AND THE SUN
OUR EXPERTISE
Our Philosophy
Institut Esthederm trusts the skin’s natural resources.
Rather than overprotecting it with an external shield,
Esthederm sun care products teach the skin how to
ensure its own protection.
The Photo Cellular Care line re-educates the skin to
adapt itself to the sun by stimulating its self-defense
abilities, especially by synthesizing its own biological shields
against UV rays.
Our Technologies
Theseunique treatments are based on 2 patented technologies, the
outcome of 30 years of expertise in photo-biology:
UV INCELLIUM:
A biological cell protectionpatented technology against UV rays
aggressions. Reinforces the skin’s natural self-defense and adaptation
capacities to the sun.
ADAPTASUN:
A pigmentation process activation patent
, which strengthens the skin’
s
natural protectionmechanism: the tan.
These technologies combine, when necessary with
external protection
(screens and filters)
adapted to sun radiation strength as well as skin
sensitivity.
UV inCELLIUM
UV UV in Cellium technology, internal protection patent,
retains only the light’s positive effects.
•Patented formula able to strengthen the skin’s natural self-
defense abilities against sunlight

•Reproduces protection and reparation process
, which cells
and skin tissues naturally develop while exposed to sunlight by re-
stimulating them: anti-radical protection, anti-inflammatory
mechanisms, DNA protection and HSP synthesis to repair damaged
proteins.
UV inCellium self-protection systems:
‒Anti-radicals protection:
protects the cells from a possible excess
of free radicals by stimulating the skin’s anti-oxidizing own defenses,
by bringing the necessary secondary anti-oxidants (Vitamin E) and by
trapping the radicals species formed.
This protection is the core as it neutralizes UV rays indirect aggressions.
It also participates in the DNA, cells and inflammation protection.
‒DNA protection: preserves DNA integrity by trapping free radicals
and by optimizing protection mechanisms at stake.
‒Anti-inflammatory protection:helps the skin to protect itself against
UV inflammation, induced by stimulating its own endogenous anti-
inflammatory mechanisms. Essential efficiency, as recent research
shows, the implication of inflammatory phenomenon on skin aging and
on the development process of malignant tumors.
‒HSP Synthesis: protects skin tissue by stimulating HSP70s,
chaperone molecules necessary to repair damaged proteins. The rapid
presence of HSP70 in the skin protected by UV inCellium will allow the
cells to repair themselves quickly, hence avoiding inflammatory or
oxidative consequences.
Efficiency evidence of DNA protection: comet test
Irradiated control cells show a nucleus looking like a comet, whose
length is proportional to DNA lesions.
Cells treated by UV IN CELLIUM recover a much rounder nucleus,
a sign of sufficiently protected DNA against fragmentation
Adaptasun
ADAPTASUN technology, exclusive tanning re-education patent.
•It acts at all stages of the pigmentation process: induction, synthesis and melanin
distribution, a pigment at the origin of tanning, which is a biological ultra-efficient UV ray
filter, as well, as a natural DNA and anti-ROS protector.

Modes of Action:
‒Stimulation of melanogenesis’ induction:
ADAPTASUN (biomimetic hexapeptide)
activates the production of melanin, by acting as a bait: it holds onto the MCR-1
receptor, present on the melanocyte, the same way α-MSH (messenger inducing
pigmentation) would do. This holding action triggers numerous reactions leading to
melanin synthesis.
‒Activation of melanin synthesis: ADAPTASUN (trace elements and specific amino
acids: tyrosine precursors + copper) stimulates tyrosinase, melanogenesis key enzyme
allowing the transformation of L-Tyrosine (essential amino acid) into L-dopa then into
Dopaquinone, the common precursor of melanin; it also brings stabilized Tyrosines (1
fat-soluble and 1 hydro-soluble) which are melanin precursor substrates.
‒Improvement of melanocyte melanin transfer to the keratinocyte:by increasing
the melanocytes’ dendricity, (Vitamin F + Diol) encourages the homogenous
distribution of melanin in the epidermis, hence encouraging the homogenous spreading
of pigments in the epidermis.
Clinical efficiency evidence:
•Increase the speed of tanning, its intensity and durability
•Within 4 days of UV ray exposure, the skin is tanned as if exposed for 12 days.
•This rapid pigmentation of the skin
encourages its natural protectionand allows it
to adapt betterto subsequent UV ray exposures.
UV inCellium /
Adaptasun
Tanning treatments of the PHOTO CELLULAR CARE line allow
the skin to benefit from the sun’s positive effects with a
unique ADAPTATION technology which allows the skin to act
with the sun and not against it.
Various skin types react differently to sunlight.
Institut Esthederm distinguishes 2 skin types and several degrees of
sensitivity:
Our vision of the skin
Normal tolerant skinswhich tan with rare sunburns.
Their objective is to tan quickly and safely while controlling photo-aging.
Intolerant skins which are either reactive or deficient(pigmentation spots,
scars, allergies to chemical filters…).
Their objective is to sunbathe moderately without suffering and
without risk of skin reaction.
The Photo cellular Care line answers all needs by a specific and
adapted offer.
Our sunlight doses
3 levels of sunlight intensity:
Since the beginning, Institut Esthederm has claimed to:
•Develop offers which work in harmony with the nature of sunlight
•Offer a sun care line adaptable to all levels of sunlight intensity
Our Objective
Allowing all skin types to benefit from the sun safely while
preserving skin youth.
For tolerant and intolerant skin types to adapt to all levels of UV ray
or sunlight intensity.
Our Objective
Offer Segmentation
SUN CARE TREATMENTS
Products for all skin types under all sunlight conditions

Tanning quickly and safely:
For tolerant skin tanning care for gentle, normal to strong, extreme sun
All skin type: Adaptasun
Anti-wrinkle: Bronz Repair

Sunlight exposure without tanning
All skin type: No Sun
AFTER SUN TREATMENTS
Face and body products bringing all necessary elements to repair and
soothe the skin after sun exposure.
SUN SHEEN TREATMENTS
Self-tanning and makeup sun products to keep a tanned complexion all
year long.

SUN CARE TREATMENTS
ADAPTASUN
Tanning safely and quickly
What?
Face and body sun care products.
For tolerant skin.
To adapt according to sunlight intensity.
How?
Products adapted to the 3 levels of sunlight intensity thanks to the right
dose of external protection’s active ingredients.
PATENT:
UV inCellium, Adaptasun, Cellular Water
Which?
Normal tolerant skin: tan with rare sunburn.
Textures:
Face: light and comfortable creams developed especially for face and
décolleté exposures.
Body: Creamy and velvety lotions with a satin finish for a golden body
Results:
The tan is quicker, more intense and safe, regardless of
sunlight intensity.
BRONZ REPAIR
Tanning without wrinkles
What?
Anti-wrinkle tanning treatment cream dedicated to the face .
Allows tolerant skin to tan without wrinkles.
To adapt according to sunlight intensity.
How?
Products adapted to the 3 levels of sunlight intensity thanks to a precise association
of actives of Cellular Protection, External Protection and of the Repair patent.
Strengthen the natural abilities of the skin, stimulate the tan and the cellular and
tissue regeneration under all types of sun.
PATENT:
UV inCellium, Adaptasun, Repair, Cellular Water
Which?
Tolerant skin concerned with preserving its youth.
Textures:
Light and comfortable creams developed especially for face and décolleté sun
exposures.
Results:
The tan is quicker and more intense. The skin’s youth is preserved
NO SUN
Sunlight exposure without tanning
What?
Maximum protection sun care product for deficient intolerant skin (scars) or for
those wishing to spend time in the sun without tanning, regardless of sunlight
intensity.
How?
Treatment adapted to skin deficiency thanks to the optimal concentration of
Cell protection (UVInCellium patent) and external protection’s active
ingredients, adapted to all sunlight conditions.
PATENT:
UV inCellium, Cellular Water
Which?
Deficient intolerant skin, wishing to spend time in the sun without tanning.
Texture:
Light and comfortable cream.
Results:
The skin can be exposed to the sun without tanning
AFTER-SUN TREATMENTS
Soothing the skin and prolonging the tan’s glow
What?
Face and body after-sun treatments for all skin types which provides
all the necessary elements to comfort the skin after sun exposures.
Which?
All skin types.
AFTER-SUN REPAIR
Anti-wrinkle cream fluid, soothing and prolonging the tan, especially
developed for the face and décolleté. Repairs photo-aging.
PATENT: Repair, Adaptasun
REFRESHING AFTER-SUN FONDANT
Fresh gel, soothing and complimenting the body’s tan.
PATENT: Repair
TAN EXTENDING LOTION
Creamy and velvety body lotion to preserve a glowing tan, longer.
PATENT: Adaptasun, Repair
Results:
A glowing and sublime tan which lasts much longer
SUN SHEEN TREATMENTS
Keeping a golden tanned complexion all year long
What?
Self-tanning and makeup sun treatments for the face and body for all skin types, for a
natural healthy glow all year long without sun.
Which?
All skin types.
SUN SHEEN SELF-TANNING PRODUCTS
Intelligent treatments which create the perfect replica of a natural tan.
2 offers according to the tanning objective:
Soft and progressive tan: face self-tanning cream and body self-tanning lotion.
Intense and instantaneous tan: face self-tanning cream and body self-tanning gel.
SUN SHEEN MAKEUP PRODUCTS
Treatments which adapt to all color complexion types to create a daily natural tan.
Treatment powder: sun powder for the face and décolleté which protects and
sublimates all skin types.
Results:
A healthy glow all year long.
© 2010 First Impression Studio